IN VITRO ANTIFUNGAL EFFICACY OF BIOACTIVE COMPOUNDS HEPTADECANE, 9- HEXYL AND OCTADECANE, 3-ETHYL-5-(2-ETHYLBUTYL) FROM LEPIDAGATHIS CRISTATA WILLD. (ACANTHACEAE) ROOT EXTRACT.

Dr. M. N. Abubacker* and P. Kamala Devi

ABSTRACT

To identify bioactive compounds Heptadecane, 9- hexyl and Octadecane, 3-ethyl-5-(2-ethylbutyl) from Lepidagathis cristata Willd. (L. cristata) root extract to assess antifungal potentials of the isolated compounds.Aqueous extracts of L. cristata roots were used for this study. The major bioactive compounds isolated were tested for antifungal activities. The major bioactive compounds Heptadecane, 9- hexyl and Octadecane, 3-ethyl-5-(2-ethylbutyl) were isolated from the roots of L. cristata and these compound were tested for antifungal potentials and found to be highly effective to plant pathogenic fungi Colletotrichum fulcatum NCBT 146, Fusarium oxysporum NCBT 156 and Rhizoctonia solani NCBT 196 as well as for the human pathogenic fungi Curvularia lunata MTCC 2030 and Microsporum canis MTCC 2820.The results justify the antifungal potentials of both plant and human pathogenic fungi. The plant bioactive compounds will be helpful in herbal antifungal formulations.

Keywords: Bioactive compounds Heptadecane, 9- hexyl, Octadecane, 3-ethyl-5-(2-ethylbutyl), GC-MS analysis.