EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION STUDIES OF EMULGEL CONTAINING MEFENAMIC ACID

Fairusa Musthafa, Dr. Suja C. and Shuhaib B.*

ABSTRACT

The objective of the present investigation was formulate & characterize the emulgel containing mefenamic acid.Mefenamic acid emulgel using HPMC and NaCMC as gelling agent were successfully developed. The developed formulations were then characterized for their physical appearance, pH, viscosity, spreadability, extrudability, drug content and in vitro release. The emulgel (CF1) prepared using HPMC as gelling agent, propylene glycol as co- surfactant and clove oil as penetration enhancer was found to show better result when compared to emulgel (CF2) prepared using NaCMC as gelling agent. In CF1, correlation coefficient of zero order kinetics was found to be R2 = 0.995 and that of first order kinetics was to be R2=0.771.Higuchi plot was found to be linear with regression coefficient R2=0.902. Hence it shows that the drug release follows zero order kinectics.To confirm exact mechanism of drug permeation from the emulgel, the data was fitted according to the Korsmeyer- Peppas model.The value of slope of the plot n gives an indication of the release mechanism. When n=1, the release is independent of time i.e., zero order, if n=0.5 then the release is by Fickian diffusion. When n= 0.5-1, diffusion is non-fickian and when n>1.0 then it is super case II transport. The ‘n’ exponent value of optimized batch was found to be 0.651. Hence it shows non-fickian diffusion.

Keywords: Mefenamic acid, emulgel, release kinetics.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)