EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

PLASMA HIGH SENSITIVE C-REACTIVE PROTEIN IN EARLY PREGNANCY AS A MARKER OF PRETERM DELIVERY A CASE –CONTROL STUDY

Dr. Devyani Tiwari* and Dr. Sumitra Yadav

ABSTRACT

A nested case control study was carried out to evaluate the association of early pregnancy high sensitive C-reactive protein (HsCRP), a marker of inflammation, with preterm delivery. Subjects were 92 women who delivered preterm (<37 weeks’ gestation) and 92 controls (term deliveries) matched on age, race/ethnicity, height and weight. High-sensitivity CRP assays which was measured by immunoturbidimetry assay and followed till delivery were performed on early-pregnancy (< 21 weeks gestation) plasma samples. Odds ratios and 95% confidence intervals were estimated by using conditional logistic regression adjusted for matching factors, gestational age at blood collection, and pre pregnancy body mass index. Median concentration of CRP was 3.65 mg/liter in cases versus 2.76 mg/liter in controls. No significant association was found between quartiles of CRP and preterm delivery. However, CRP levels >7 was significantly associated with the increased risk of preterm delivery (p <.0096;odds ratio 6.11; 95% CI1.31-28.39) These findings suggest that very high CRP levels in early pregnancy are associated with preterm delivery.

Keywords: ABBREVIATIONS: CI- confidence interval; hsCRP- high sensitive C-reactive protein; OR-odds ratio.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)