EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

NASOPHARYNGEAL RHABDOMYOSARCOMA: A CASE REPORT

Dr. Sunita Singh (Senior Professor), Dr. Bharti Sharma (Junior Resident), Dr. Ritesh Kumar Sheorain* (Junior
Resident) and Dr. Rajeev Sen (Senior Professor and Head of the Department)

ABSTRACT

Introduction: Rhabdomyosarcoma is a soft tissue sarcoma arising from cells of myogenic lineage. Most common sites being extremities, perirectal and perineal region. It is a malignant tumor of soft tissue in children under 15 years of age, accounting 5% to 10% of all childhood malignancies. Head and neck region is frequently involved in childhood. For pediatric rhabdomyosarcoma cases, most of them have orbital primaries in the head and neck region, nasopharynx and nasal cavity cases are rarely seen. Case Report: An 11 years old boy presented with history of nasal mass, nasal obstruction and epistaxis. These symptoms started 4 to 5 months back and gradually progressed. The histological diagnosis of rhabdomyosarcoma was confirmed by immunohistochemistry method. We report this case because of its unique location in nasopharynx. Discussion: Rhabdomyosarcoma originates from immature mesenchymal cells that are committed to skeletal muscle differentiation. It is the most frequent soft tissue tumor in children. Histologically, it is distinguished in 3 types: embryonic, alveolar and pleomorphic. Embryonic type is mainly affect children less than 5 years of age. Pediatric rhabdomyosarcoma cases in head and neck region mainly have orbital primaries whereas nasopharynx and nasal cavity rhabdomyosarcoma cases are rarely seen. Only histology with immunohistochemistry provides specific diagnosis, in the form of diffuse desmin and myogenin staining. Conclusion: Rhabdomyosarcoma is a most common type of soft tissue sarcoma in children. It is localized in the head and neck region in 40% cases. Treatment of rhabdomyosarcoma is complex, including multi-drug chemotherapy, radiotherapy and surgery.

Keywords: Rhabdomyosarcoma, Nasopharynx, Myogenin.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)