EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

OLFACTORY ESTHESIONEUROBLASTOMA: STUDY OF 5 CASES AND REVIEW OF THE LITTERATURE

Khaoula Hafidi*, Omar Oubry, Hasnae Taghzout, Zineb Alami, Touria Bouhafa and Khalid Hassouni

ABSTRACT

Introduction: Esthesioneuroblastoma is a rare malignant tumor, which develops from olfactory neuroepithelium and is one of the rarest tumors of the nasal cavity. The aim of this study is to specify through a review of the literature, histoclinic characteris- tics, therapeutic terms and prognostic factors of this tumor. Material and methods: a retrospective study concerning five cases of olfactory neuroblastoma treated in the department of radiation therapy at the departmentof radiotherapy University hospital Center Fes Morocco. Results: The mean age of our patients was 40 years. Clinical symptomatology was dominated by nasal obstruction and epistaxis. Four patients were classified as Kadish C and one patient as Kadish D. Four patients underwent surgical treatment, 3 of them had postoperative radiotherapy. One patient was above all therapeutic resources. One patient is in complete remission with a mean follow-up of 3 years. Conclusion: olfactory esthesioneuroblastoma is a rare sinonasal malignant tumor, characterised by clinical polymorphism and local agressivity. In spite of the surgery and the radiotherapy, the forecast remains reserved in the long term.

Keywords: Olfactory neuroblastoma, Imagery, Immunohistochemestry, Surgery, Radiotherapy.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)