OLFACTORY ESTHESIONEUROBLASTOMA: STUDY OF 5 CASES AND REVIEW OF THE LITTERATURE
Khaoula Hafidi*, Omar Oubry, Hasnae Taghzout, Zineb Alami, Touria Bouhafa and Khalid Hassouni
Introduction: Esthesioneuroblastoma is a rare malignant tumor, which develops from olfactory neuroepithelium
and is one of the rarest tumors of the nasal cavity. The aim of this study is to specify through a review of the
literature, histoclinic characteris- tics, therapeutic terms and prognostic factors of this tumor. Material and
methods: a retrospective study concerning five cases of olfactory neuroblastoma treated in the department of
radiation therapy at the departmentof radiotherapy University hospital Center Fes Morocco. Results: The mean age
of our patients was 40 years. Clinical symptomatology was dominated by nasal obstruction and epistaxis. Four
patients were classified as Kadish C and one patient as Kadish D. Four patients underwent surgical treatment, 3 of
them had postoperative radiotherapy. One patient was above all therapeutic resources. One patient is in complete
remission with a mean follow-up of 3 years. Conclusion: olfactory esthesioneuroblastoma is a rare sinonasal
malignant tumor, characterised by clinical polymorphism and local agressivity. In spite of the surgery and the
radiotherapy, the forecast remains reserved in the long term.
Keywords: Olfactory neuroblastoma, Imagery, Immunohistochemestry, Surgery, Radiotherapy.
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