EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTIMICROBIAL SUSCEPTIBILITY OF COMMON PATHOGENS ISOLATED FROM PAEDIATRIC COUGH SYRUPS IN PORT HARCOURT METROPOLIS, NIGERIA

Nkechi Obiofu Ezenobi*, Hanson Ige Ogbu and Dumle T. Kpea

ABSTRACT

The presence of unwanted microbes or their metabolites in pharmaceutical products especially syrups are rapidly becoming a matter of public health concern worldwide. Patients being treated with these contaminated syrups can have secondary infection from the pathogenic microorganisms which may complicate the treatment procedure since syrups are mostly administered to children whose immune systems are not well developed. Hence this study was conducted to determine the susceptibility of common pathogens isolated from cough syrups sold in Port Harcourt metropolis. A total of fifty cough syrups were randomly purchased from approved pharmacy outlets within Port Harcourt metropolis and subjected to macroscopic assessment, isolation, characterization, pH, stability as well as susceptibility-resistance test of isolates using standard techniques. The result indicated that 70% of the cough syrup did not show growth while 30% of the syrups were contaminated with microorganisms which were above the acceptable limit (<102 and <101 CFU/mL for bacteria and fungi respectively) as specified by the USP. The major contaminants in the cough syrup were Staphylococcus aureus (35.29%), Pseudomonas aeruginosa (29.43%), Escherichia coli (11.76%), Candida albicans (11.76%), Klebsiella pneumoniae (5.88%) and Proteus species (5.88%). The pH value of the cough syrups ranged from 2.76 to 7.40, hence, 96% of the syrups were acidic. For the stability test, 4 out of the 50 samples failed the test. The antibiotic susceptibility testing showed that the isolates had single and multiple drug resistance patterns to the antibiotics used, hence the existence of pathogenic microorganisms in the syrups poses serious health problem to the consumers. A routine microbiological study of these drugs is thus suggested along with good manufacturing practice.

Keywords: Antimicrobial, Susceptibility, Contamination, Pathogens, Paediatric, Cough Syrup.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)