EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

THE AMELIORATIVE ROLE OF GINGER ADMINISTRATION AGAINST GABAPENTIN-INDUCED HEPATOTOXICITY IN RAT FETUSES

Gamal M. Badawy*, Marwa N. Atallah and Saber A. Sakr

ABSTRACT

Objective: To investigate the possible side effects of prenatal exposure to the antiepileptic drug gabapentin (GBP) on the liver during the organogenesis phase of the rat embryonic development and to examine the possible ameliorative role of ginger. Methods: Three integrated approaches namely, histological, immuno-histochemical and ultrastructural were adopted. Results: Fetuses maternally injected with GBP displayed congested central vein, disruption of normal architecture and vacuolation of the hepatocytes. The expression of Bcl-2 in the cytoplasm of hepatocytes was remarkably decreased, while the expression of Caspase-3 was increased. At the ultrastructural level, the hepatocytes had irregular shaped and shrunken nuclei. The cytoplasm appeared rarefied, vacuolated and with disrupted organelles. Oral injection of ginger after GBP resulted in evident amelioration at all the investigated levels. Conclusions: The use of GBP as antiepileptic drug should be treated with caution during pregnancy and ginger is recommended to be taken in parallel for its ameliorative role in this regard.

Keywords: Gabapentin, Adverse effects, Ginger, Amelioration, Fetal development, Liver.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 March 2019 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR MARCH ISSUE PUBLISHED

    MARCH 2019 Issue has been successfully launched on 1 March 2019

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 4.161 to 4.897 due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)