COMPARATIVE EFFICACY OF TWO POLYHERBAL CREAMS WITH FRAMYCETIN CREAM IN TREATING FRESH WOUNDS

Minakshi Nehete, Sanjay Nipanikar, Anisha Kanjilal, Sanjeevan Kanjilal, Pratima Tatke

ABSTRACT

Restoration of damaged tissue, wound or facture is an important process which plays vital role in survival of life. The medicinal plants used in formulation of Cream A (Ari’s Wound Healing Cream) and Cream B (Amarantha Wound Healing Cream) have long been used in traditional Indian System of Medicine and serve as the principal herbs in treating wound. Market survey revealed that very few formulations are available in the market to enhance wound healing process. This prompted us to assess wound healing efficacy of two Polyherbal topical creams in albino rats. Wound healing activity was evaluated using incision and excision wound models in albino rats. The results demonstrated that on 16th day, the % wound contraction of excision wounds treated with cream A and cream B (91.86 + 2.57 % and 98.13 + 0.72 % respectively) was better than wound treated with Framycetin Sulphate cream (89.43 ±3.280%). Epithelialization period of wounds treated with cream A (day 23) and cream B (day 17) was found to be significantly (p<0.05, p<0.001 respectively) lower as compared to wounds treated with Framycetin Sulphate cream (day 27). Breaking strength of wounds of animals treated with Cream A (583.33 ± 9.54) and Cream B (650 ± 18.25) was found to be lower as compared to tensile strength of incised wounds treated with standard (Framycetin sulphate cream). Results of in vivo experiments indicate that polyherbal cream A and cream B exert significant wound healing activity, demonstrating its relevant therapeutic potential

Keywords: Polyherbal cream, Excision wound, Incision wound, Framycetin sulphate cream.