EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

STUDY OF PROTECTIVE EFFECTS OF PISTACIALENTISCUS LEAVES AQUEOUS EXTRACT AGAINST GASTRIC ULCER AND RENAL STONE FORMATION IN RATS

Rachida Aboufatima, Jawad Laadraoui, Mehdi Ait Laaradia, Kenza Bezza, Zineb El Guebbas, Sara Oufquir, Hind Ferehan, Abderrazak EL Alami, Sokar Zahra and Abderrahman Chait*

ABSTRACT

Medicinal plants have been used by all societies since ancient times as medicines for the treatment of many diseases. In Morocco, the use of medicinal plants is an important part of the cultural diversity of population. The objective of this data is to investigate the protective effects of the aqueous extract of Pistacialentiscusleaves (AEPL) (50, 100 and 200 mg/kg) against kidney stones formation and gastric ulcer induced by ethylene glycol (EG) and by HCl/Ethanol respectively. In EG experiment, blood was collected to estimate calcium, phosphorus, creatinine and urea levels. The presence of stones was detected by microscopic observation of renal tissue sections. The obtained results showed that the higher amounts of calcium, phosphorus, urea and creatinine observed in EG/AC treated animals were decreased by AEPL treatment. Histology observation indicated that the number of calcifications in renal tissues of rats treated by AEPL given orally, were significantly reduced compared to the EG/AC group. On the other hand, the important antiulcerogenic effect observed in rat treated with AEPL is dose dependent. This data suggests that AEPL has a protective property against urolithiasisand gastric ulcer justifying its popular use in Morocco as an anti-urolithiasis and anti-ulcer agent.

Keywords: Plentiscus; Urolithiasis; Ethylene glycol; stone formation; gastric ulcer.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)