EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

PLASMID-MEDIATED RESISTANCE IN EXTENDED SPECTRUM BETA–LACTAMASE–PRODUCING KLEBSIELLA PNEUMONIAE ISOLATES AT RIVERS STATE UNIVERSITY TEACHING HOSPITAL

Monsi Tombari Pius*, Abbey Samuel Douglas, Wachukwu Confidence Kinikanwo and Wokem Ngozika Gloria

ABSTRACT

Background: The presence of plasmid association with emergence and transmission of antimicrobial–resistant bacteria a serious health issue in developing countries. Aim: The aim of this project is to phenotypically and molecularly analyse the antimicrobial resistance induce in K. pneumoniae. Methods: The clinical isolate was identified both phenotypically and molecularly by amplification and sequencing of the 16S rRNA. The ability of the clinical strain to produce beta–lactamase enzyme was determined by performing antimicrobial sensitivity to Penicillin, Ampicillin, Cefoxitin and Ceftriaxone. Presence of plasmid in the K. pneumoniae clinical and laboratory strains were examined. Polymerase chain reaction amplification of the beta–lactamase genes blaTEM-1 and blaSHV was performed. Results: From the 30 isolates investigated, only 7 were positive for Klebsiella sp while 23 were negative. This gives a 23% incidence of Klebsiella sp in Enterobacteriaceae isolates in patients’s samples at Rivers State University Teaching Hospital (RSUTH). From the seven confirmed K. pneumoniae isolates, only three isolates were positive for the presence beta–lactamase production as they were considered resistant. Conclusion: These results show that 10% of Klebsiella sp found in RSUTH possess beta–lactamase which is responsible for the resistance to beta–lactam drugs.

Keywords: Plasmid, Resistance, Nosocomial, Klebsiella pneumonia.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 February 2019 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR FEBRUARY ISSUE PUBLISHED

    FEBRUARY 2019 Issue has been successfully launched on 1 February 2019

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 4.161 to 4.897 due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)