EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTIDEPRESSANT AND ANXIOLYTIC EFFECT OF ETHANOL EXTRACT OF FICUS PLATIPHYLLA STEM BARK IN MICE

Olapade M. K., Wakeel O. K.*, Ayankunle A. A., and Abe A. I.

ABSTRACT

The present study evaluated the effect of ethanol extract of Ficus platiphylla stem barks in the doses of 20, 40 and 80 mg/kg on anxiety and depression using mice as a model. Ethanol extract of Ficus platiphylla stem barks increased significantly the number of square crossed (center and peripheral), duration at the center of the field and rearing frequency, while there was significant reduction in duration of grooming in open field test. In the elevated plus maze experiment, the number of entries and duration of time in the open arms increased significantly with Ficus platiphylla stem barks extract treated groups. These aforementioned behavoural indices were also completely nullified by flumazenil, a benzodiazepine receptors antagonist and pindolol a β-adrenoceptors blocker or 5-HT 1A/1B receptor antagonist. In the light and dark experiment, the time spent as well as the frequency in the light compartment and the number of the light-dark transitions increased significantly with Ficus platiphylla stem barks extract treatment. The extract was able to significantly reduced the immobility time, while activity of the mice in swimming and climbing increases significantly. In conclusion, the present study revealed the anxiolytic and antidepressant effects of the ethanol extract of Ficus platiphylla stem bark and the propable mechanism of action might be mediated via benzodiazepinergic and noradrenergic pathway.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)