EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

TREATMENT OF LARYNGEAL AND HYPOPHARYNGEAL CANCER IN THE ELDERLY FROM THE AGE OF EIGHTY

Raphael Fernandes Calhau* MD, Terence Farias MD, MsC, PhD, Researcher, Adeilson Moreira Júnior MD, Emílio Tosto Neto MD and Fernando Luiz Dias MD, MsC, PhD, FACS

ABSTRACT

Introduction: Characteristics of the Brazilian population have been changing in the recent decades. A growth of the senior population since the eighties has resulted in alteration in the incidence of the diseases and mortality. Objective: to study the epidemiological and prognostic factors and predictive responses of squamous cell carcinoma of larynx or hypopharynx treated in patients with 80 years or older. Methods: a retrospective study analyzed the medical records of 38 patients with 80 years or older treated for larynx or hypopharynx cancer at the National Institute of Cancer, Rio de Janeiro, (INCA/MS) between January 2015 and December 2018. Gender, age, stage, treatment carried out and the patients' clinical evolution were analyzed. For the statistical analysis, the p value was considered significant when smaller than 0.05, when calculated by the qui-square method and the regression of Cox. The survival curves were analyzed by the Kaplan-Meyer method. Results: twenty-seven elderly patients with larynx cancer and 11 with hypopharynx cancer were included, being 26 (68.4%) men and 12 (31,6%) women. The mean age was 84.8 years (80 to 94 years). Seventy-nine percent of patients had stages III or IV of disease. Eighteen patients (47.4%) were treated, 6 (15.8%) underwent surgery at some point of the treatment. Twelve patients (44.4%) were treated by exclusive radiation therapy, with an average dose of 51.4 Gy (6–70 Gy). Complete response of treatment was achieved in 13 cases (48.1%), eight of them treated solely by radiation therapy, 3 by surgery alone and 2 by surgery combined with radiotherapy. The incidence of recurrence was 26.3% (10 cases) and death occurred in 24 cases (63.1%). The mean disease-free survival was 11 months, and mean overall survival was 10.3 months. The most important prognostic factors to increase mortality were the tumor size (p = 0.04) and stage of disease (p = 0.03). No difference in survival was noted comparing treatment modalities (p = 0.53). Conclusion: the most important prognostic factors to increase mortality were tumor size (p = 0.04) and stage of disease (p = 0.03). There was no variable evidence of prognostic impact in recurrence of the disease. Treatment modality in this group of patients showed no difference in disease-free survival and overall survival.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)