EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

HEAT STABILITY AND PROTEASE INHIBITORY PROPERTIES OF 28KDa GLYCOPROTEIN FROM TURMERIC (CURCUMA LONGA)

Dinesha Ramadas, Shobith Rangappa, Santhosh Kumar N.*, Chikkanna D., Manjula R. V.,  Tejaswini B.M, Divya Y.

ABSTRACT

Turmeric (Curcuma longa) belongs to Zingiberaceae family extensively used as food colourant, flavour, spice and as medicine in Middle Asia and South East Asian countries. Herein we are reporting the property of heat stability and proteases like trypsin and chymotrypsin inhibitory property of glycoprotein of 28kDa from Curcuma longa. It exerts inhibitory activity protease Trypsin and Chymotrypsin up to 53 and 57% at 100μM dosage respectively. The protein alone shows 67% inhibition and standard antioxidant Ascorbic acid shows 65%. This protein was stable up to a temperature of 1000C, active over a wide range of pH from 2 to 12, specifically more at weak acidic and neutral pH and less at basic pH. This is the first report on protease inhibitor activity and heat stability activity of glycoprotein of 28kDa from Turmeric (Curcuma longa).

Keywords: Turmeric, Curcuma longa, Heat stability, Protease inhibitors, trypsin and chymotrypsin.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)