SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVAL IMIDAZOLE BASED COMPOUNDS
Bipin Kumar Verma*, Sunil Kapoor and Girendra Gautam
Some new imidazole derivatives (3i-xii) were synthesized as per design synthetic protocol scheme. The structures of newly prepared compounds were confirmed by modern analytical technique and elemental analysis. All the synthetic compounds were screened for their antimicrobial activity against bacterial results showed good to remarkable activity. The MIC (minimum inhibitory concentration) values were determined by comparison to ciprofloxacin (anti-bacterial) and fluconazole (anti-fungal) as standard drug. Among them, compound 3iv and 3x exhibited notable antimicrobial activity. These compounds may be used as new template for the searching of potential antimicrobial agents.
Keywords: Imidazole, Biphenyl ethanone, Antibacterial activity and Antifungal activity.
[Full Text Article]