EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ASSOCIATION OF XRCC1 399GLN AND XRCC3 T241 METH POLYMORPHISM WITH THE RISK OF CERVICAL CANCER IN NORTH INDIAN POPULATION

Mark Rector Charles, M.Sc, Syed Tasleem Raza*, Ph.D, Pushpendra Pratap, M.Sc, Rolee Sharma, Ph.D, Jamal Mohd. Arif, Ph.D and Ale Eba, M.Sc

ABSTRACT

Association of XRCC1 399Gln and XRCC3 T241 Meth polymorphism with the risk of cervical cancer in North Indian Population. Objective: To study the association of polymorphisms in the DNA repair genes of x-ray repair cross-complementing (XRCC) gene 1 399Gln and XRCC3 T241M, to the susceptibility of cervical cancer (CC) in North Indian population. Material and Methods: XRCC1 & XRCC3 polymorphisms were characterised in Seventy-one eligible CC patients and Sixty nine healthy controls who had no history of any malignancy by using confronting two pair primers (PCR–CTPP) method, taking DNA from peripheral blood in a case control study. Results: Our results revealed that the frequencies of AA genotype of XRCC1 399 polymorphism were significantly higher in the CC patients than in the normal individuals (p 0.001), OR=5.27, 95% CI= (1.934-14.372). While we did not observe any association between the XRCC3 T241M polymorphism and CC risk. Conclusion: Our results suggested that, XRCC1 399 gene is an important candidate gene for susceptibility to cervical cancer. Although the sample size was small, the present study indicate a statistical association between cervical cancer and XRCC1 399Gln polymorphism. Future studies are needed that may provide a better understanding of the association between gene polymorphism and cervical carcinoma risk.

Keywords: XRCC1, XRCC3, Gene polymorphism, Cervical cancer.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)