EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

SYNTHESIS AND BIOLOGICAL SCREENING OF A NOVEL CLASS OF POTENTIAL ANTI-INFLAMMATORY AGENTS

Somashekhar M.* and R. B. Kotnal

ABSTRACT

A series of novel 5[4-Morpholin-4-yl-Phenyl)-1, 3, 4-oxadiazole 2-thiol were synthesized by the morpholie and 4-chloro-benzonitrile on reflux gives 4-(morpholine-4-yl) benzonitrile. This upon treating with sodium hydroxide gives 4-(morpholin-4-yl) benzoic acid. Then this upon treating with thionyl chloride gives 4-(morpholin-4-yl) benzoyl chloride. This on further treatment with hydrazine-hydrate gives 4-(morpholin-4-yl) benzohydrazide which is treated for cylcisation with carbon disulphide in presence of potassium hydroxide gives resultant compound 5[4-Morpholin-4-yl-Phenyl)-1,3,4-oxadiazole 2-thiol then it is treated with various substituted to form 1, 3, 4-oxadiazole derivatives. Hydrazides were synthesized so as to increase intracellular concentration and so as to try and decrease the resistant developed due to decrease intracellular concentration of the drug. These synthesized compounds were subjected to preliminary biological evaluation. The characterization of synthesized compounds was identified on the basis of IR, 1HNMR, Mass spectroscopy. The compounds have been evaluated for anti-inflammatory activity.

Keywords: Morpholine, P-Chlorobenzonitrile, 1, 3, 4-Oxadiazole, Anti-inflammatory activity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)