DESIGN AND EVALUATION OF ENTERIC COATED FORMULATIONS FOR AN ANTI-INFLAMMATORY DRUG BASED ON MODIFIED RELEASE POLYMERS
E.E. Zien El-Deen*, M.M. Ghorab, S. Gad, H.A. Yassin
ABSTRACT
Ketorolac is a potent non-steroidal drug with potent analgesic and anti-inflammatory activity. Its oral
administration is associated with a high risk of adverse effects such as irritation, ulceration and bleeding of
gastrointestinal tract. The present study focuses on the development of controlled release drug delivery system of
ketorolac microcapsules as one of the multi-particulate formulations and are prepared to obtain prolonged drug
delivery in order to decrease ulcerogenicity, improve bioavailability or stability and target a drug at specific
sites. Microcapsules were prepared using Eudragit RS100, Eudragit RL100 and ethyl cellulose in ratios of 1:1, 1:2
and 1:3 drug to polymer. IR, DTA and X-ray investigations revealed that there was no interaction between the drug
and the polymers used. The in-vitro release studies showed that the release rate of the drug has been
modified. This study presents a new approach based on microencapsulation technique for obtaining modified
release drug delivery system.
Keywords: Ketorolac, DTA and X-ray investigations, Eudragit RS100, Eudragit RL100.
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