EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTIBIOFILM ACTIVITY AND THE SYNERGISTIC EFFECT OF LEMON GRASS ESSENTIAL OIL WITH ANTIBIOTICS AGAINST A.BAUMANNII COMPLEX – A PRELIMINARY REPORT

Aparna Shivaprasad*, Beena Antony and Rekha B.

ABSTRACT

Introduction- The epidemiology and antibiotic resistance of A.baumannii have been extensively reviewed but the pathogenesis and virulence remain unclear. Biofilm formation is a well-known pathogenic mechanism in device related infections. High incidence of resistance to pharmaceutical antibiotics among microbes in hospital environment prompts the search for alternative source of antimicrobial chemicals with anti-biofilm activity. Materials and Methods- Biofilm formation and antibiofilm activity of Lemon grass essential oil [LGO] in 251 Acinetobacter clinical isolates was detected by polystyrene tissue culture plate method and modified crystal violet assay respectively. The broad-spectrum antimicrobial activity of LGO in combination with antibiotics against multidrug resistant & extremely drug resistant A.baumannii complex was also investigated. Results and Discussion- Among 251 A.baumannii isolates, 70% isolates showed biofilm formation which indicated that they were established nosocomial pathogens. About 65-79% of anti-biofilm activity was seen at the dilutions 0.625 μl/ml to 0.156 μl/ml, indicating that LGO had a significant role in inhibition of biofilm formation by A.baumannii. There was almost two fold enhancement of the antibacterial activity of the antibiotics on A.baumannii when used in combination with LGO. Conclusion- The antibiofilm activity of Lemon grass essential oil with its potentiating effect on antimicrobials by twofold might open a new avenue for determining better treatment option for A.baumannii infections as well as preventing the dissemination of nosocomial MDR & XDR A.baumannii.

Keywords: Cymbopogon flexuosus [Lemon grass], Essential oil [EO], Biofilm, Anti-biofilm activity, Synergy, MDR/XDR AB.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)