EVALUATION OF PHARMACOLOGICAL ACTIONS OF DERIVATIVES OF 4- THIAZOLIDIONES AND 1,3,4- THIADIAZOLES

Shail Modi* and Gayatri Aggarwal

ABSTRACT

The project involves evaluation of pharmacological actions of derivatives of 4-thiazolidinone and 1, 3, 4- thiadiazoles. The derivatives were investigated for various activities such as inflammation, analgesia and some CNS activities such as CNS depressant, anti-psychotic and skeletal muscle relaxant activity. In-vitro test like membrane stabilization and protein denaturation and in-vivo activities such as mice paw edema, cotton pellet granuloma, forced swim test, locomotor activity were carried out to know the pharmacological activities of the test drugs. It was concluded that the derivatives had anti-inflammatory and analgesic property without development of ulcers. They also showed muscle relaxant property and depressant characteristics which could be helpful for sedation. Further investigations were still required for confirmation of CNS activities.

Keywords: Inflammation, 4-thiazolidione, 1,3,4-thiadiazole, forced swim test, catalepsy.