EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTIOXIDANT PROPERTIES OF SECONDARY METABOLITES IN AQUEOUS EXTRACTS OF FICUS THONNINGII BLUME TESTED ON WISTAR RATS

Estella Tembe Fokunang, Jessica Ketchemen Pougoue, Borgia Njunkio, Joseph Ngoupayo, Palmer Masumbe Netongo, Patrice Mimche, Donatien Gatsing and Charles Ntungwen Fokunang*

ABSTRACT

Introduction: Traditional medicine methods have had a very long history to treat every sort of health disorder. The World Health Organization estimates that around 80 % of the world population in developing countries relies on traditional plant medicines for primary health care needs, of which a major proportion corresponds to plant extracts or their active principles. Plants and herbs have been used since ancient times to treat different gastrointestinal illnesses, including peptic ulcers. Objective: To identify the major classes of secondary metabolites and evaluate the antioxidant property of the aqueous extracts of Ficus thonningii. Methods: The phytochemical screening of the extracts was done using the Odebiyi and Sofowora method. Various biochemical parameters such as the Malondialdehyde (MDA), Catalase, Glutathione, Superoxide dismutase (SOD), Xanthine Oxidase (XO), were quantified using standard regulatory techniques. Results: The phytochemical screening of the extract of the F. thonningii stem bark showed the presence of the sapononins, quinones, coumarins, catechic tannins, phlobotanins, anthocyanins, flavonoids and betacyanes. The extract resulted in a non-significant increase of SOD, Catalase and glutathione in the preventive and curative activity. There was a dose-dependent significant decrease in MDA P<0.05. The MDA content was higher in the group receiving the extract 500 mg/Kg, omeprazole and healthy animals, but lower in the negative control group. Conclusion:The phytochemical screening of the extract of the bark showed the presence of the saponins, quinones, coumarins, catechic tannins, phlobotanins, anthocyanin, polyphenols, flavonoïds and betacyanes. The extract resulted in a non-significant increase of SOD, Catalase and glutathione with a dose dependent decrease in MDA. The administration of this extract with 2000 mg/Kg dose was well tolerated with no lethality observed.

Keywords: Ficus thonningii stem bark hydro-ethanolic extract, phytochemical screening, anti-oxidant, antacid, herbal medicine.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)