A PROSPECTIVE COHORT STUDY ON THE EFFECTIVENESS OF SMALL DOSE OF PROPOFOL COMPARED TO METOCLOPROMIDE FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING AFTER GYNECOLOGIC SURGERY IN TIKUR ANBESSA SPECIALAIZED HOSPITAL
Ashagrie Sintayhu and Eyayalem Melese*
Postâ€operative nausea and vomiting (PONV) is a common problem affecting 30%-70% of the patient within the first 24 to 48 hours after surgery. Propofol is an anesthetic agent used commonly for induction and maintenance. Recently its antiemetic activity at sub hypnotic low dose makes it as one prophylactic medication for Postoperative Nausea and vomiting. the Objective of this research is to compare the effectiveness of small dose of propofol with metoclopromide on prevention of postoperative nausea and vomiting after gynecologic surgery under general anesthesia at Tikur Anbessa Specialized Hospital, in Addis Ababa. It is an institutional based prospective cohort study recruits 78 patients who underwent gynecologic surgery randomly. The comparison of data showed that during the first 6 hr the incidence of postoperative nausea and vomiting were 41% with propofol group and 64.1% with metoclopromide group (p=0.041). The incidence of nausea alone have statistically significant higher association in metoclopromide than propofol group 64.1% versus 41% respectively (P =0.041) during the first 6hr but there were no statistically differences at 12 and 24 postoperative hours. The median nausea severity NRS score in the first 6 postoperative hours were lower 0 in propofol compared to 3 in metoclopromide group (p= 0.032). To conclude Small dose propofol given at the end of surgery is more effective than metoclopromide but have no difference after 6 hours to reduce the incidence and severity of post operative nausea and vomiting after gynecologic surgery. Based on these we recommend use of low dose propofol is effective antiemetic than metoclopromide in the first 6 postoperative hours.
Keywords: Small Dose of Propofol, Metoclopromide, Nausea and Vomiting.
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