EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

GASTROESOPHAGEAL REFLUX DISEASE: DIFFERENT TREATMENT APPROACHES

Paudel K. R.*

ABSTRACT

Gastroesophageal reflux disease (GERD) is chronic esophageal disorder which occurs due to reflux of gastric juice and or contents to the lower third of esophagus, and has a prevalence of 6.3 to 28% in general population. Usually, lower esophageal sphincter (LES) is dysfunctional or incompetent to prevent reflux of gastric contents to the esophagus. Serious complication of the GERD includes Barrett’s esophagus which may progress into esophageal adenocarcinoma. Use of proton pump inhibitors (PPIs) along with non-pharmacological measures is the treatment of choice in GERD. If the first choice of treatment fails, pharmacological agents other than PPIs such as H2 blockers, antacids, prokinetic agents and sodium alginate can be used. However, these agents are inferior to PPIs in terms of efficacy and side effect profile, and not indicated for long term management. A novel drug vonoprazan which is a potassium competitive blocker of H+/K+ ATPase enzyme has also been developed to manage GERD symptoms. If non-pharmacological and pharmacological approaches fail to treat the GERD, different surgical approaches such as laparoscopic fundoplication, robotic fundoplication, endoluminal suture or plication of gastroesophageal junction (GEJ), radiofrequency thermal therapy of the LES and injection or implantation of biopolymers in GEJ are useful to manage the GERD refractory to drug therapy.

Keywords: Endoscopy, Flundoplication, Gastroesophageal reflux disease, Proton pump inhibitors, Vonoprazan.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)