EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

EFFECT OF BENFOTIAMINE ON THE CORRECTED QT INTERVAL, QT DISPERSION AND SPATIAL QRS-T ANGLE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CARDIAC AUTONOMIC NEUROPATHY

Victoria A. Serhiyenko*, Galina I. Suslyk, Ludmila M. Serhiyenko and Alexandr A. Serhiyenko

ABSTRACT

Background: The significance of cardiac autonomic neuropathy (CAN) has not been fully appreciated and there is no unified treatment algorithm. Aim: To investigate the effects of benfotiamine (BFT) on the corrected QT interval (QTc), QT dispersion (QTd) and spatial QRS-T angle in patients with type 2 diabetes mellitus (T2DM) and CAN. Patients and Methods: 32 patients with T2DM and definite stage of CAN were allocated to two treatment groups: control (n = 15) received standard antihyperglycaemic therapy; group 2 (n = 17) - in addition BFT 300 mg/d for three months. The QTc interval, QTd and spatial QRS-T angle parameters were analyzed. Results: It was found out that BFT contributed to decrease of the QTc, QTd and QRS-T angle. Conclusions: The positive influences of BFT suggests the feasibility of its administration to patients with T2DM and definite stage of CAN. Obtained results suggest that the efficacy of BFT is the result of a direct effect of the BFT on the investigated indexes.

Keywords: Type 2 diabetes mellitus, Cardiac autonomic neuropathy, Benfotiamine, Corrected QT interval, Spatial QRS-T angle.

[Full Text Article] [Download Certificate]