EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTICANCER ACTIVITY OF THYMOQUINONE AND ALLICIN ON CANCER PROSTATE (PC3) AND COLON CANCER (CACO2) CELL LINES, IN VITRO STUDY

Elsayed Mohamed Mahdy, Sara Mohamed Abdu, Mohamed Ali Abd El Baseer and *Waleed Abdelwanees Mohamed

ABSTRACT

Thymoquinone and Allicine, natural products extracted from black seeds and garlic, respectively, are known as having anticancer activity. The activity of these two natural products was investigated on cancer prostate (PC3) cells and colon cancer (CaCO2) cells. The IC50 of these two compounds on PC3 cells was found to be 623.63 and 10.87 μg/ml, respectively and on CaCO2 cells was found to be 389.60 and 20.46 μg/ml, respectively. When using these concentrations in cell cycle analysis, it was found that the percent of G2-M phase and apoptosis was increased, while the percent of S phase was reduced for cells treated with these two compounds compared to control, untreated cells. Real time RT-PCR revealed that the activity of P53, caspase 3 and survivin was up-regulated, while the activity of Bcl2 was down-regulated compared to control cells. These results indicate that thymoquinone and Allicin have anticancer activity against cancer prostate (PC3) cells and colon cancer (CaCO2) cells.

Keywords: Thymoquinone, Allicin, PC3, Caco2.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)