EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

IMMUNOLOGICAL DIFFERENCES THREE NEGATIVE AND LUMINAL BREAST CANCER IN YOUNG PATIENTS

Alimhodzhaeva L.T.*, Zakirova L.T., Yusupova N.B., Khodjaev A.A., Nigmanova N.A., Norbekova M.Kh., Zakhirova N.N., Abdullaeva G.D., Narzieva D.F. and Shadmanova D.S.

ABSTRACT

Recent studies have completely changed the idea of the course of malignant diseases, in particular breast cancer (BC). For practical oncology, the addition to the conventional TNM clinical and morphological classification with the concept of four molecular biological subtypes of breast cancer has become important. Genetic classification included a variety of disease options: from luminal A, luminal B to three times negative. A completely new round of research on the biological activity of breast cancer has changed not only the clinical understanding of the process of active metastasis or its long-term latent existence in the body, but also the tactics of treatment based on the results of relapse-free and overall survival. Luminal A and three times negative variants of breast cancer are polar in many ways. Thus, the early luminal A type of breast cancer with a low risk of recurrence is subject to the hormonal system with a presumably intact immunological link of homeostasis at the system level. The standard of treatment for early luminal A breast cancer is reduced to surgery and consistent hormone therapy, since the use of chemotherapy reduces long-term results due to its toxicity, especially in the low-risk group. Three times negative breast cancer is autonomous from hormonal influence and, it is possible, it has high immunogenicity. Such patients continue the treatment for a long time in the form of sequential chemotherapy, up to regimens with compacted doses of cytostatics. The high risk of redivoting this type of breast cancer depends on the effects of growth factors and the microenvironment. With luminal A and a threefold negative type of breast cancer, the relationship between the body and the immune system is different. If in the luminal A subtype of breast cancer, there are fewer violations on the part of the immune system, then in the case of a threefold negative subtype, the violations are more pronounced.

Keywords: .


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 March 2019 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR MARCH ISSUE PUBLISHED

    MARCH 2019 Issue has been successfully launched on 1 March 2019

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 4.161 to 4.897 due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)