EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

IMPACT OF GENETIC POLYMORPHISMS IN MMPS ON THE RENAL ALLOGRAFT

Mansi Bhatt (M.Sc.) and Aneesh Srivastava* (MS, M.Ch.)

ABSTRACT

Renal transplantation (RT) is currently the most effective replacement therapy and believed as a boon for patients with end-stage renal disease (ESRD). The short-term outcomes of transplant have improved significantly, whereas the long term outcomes are still fairly compromised. The role of early acute rejections with their impact on long term graft survival has been widely recognized as one of the most important factor. The Matrix metalloproteinases (MMPs) are traditionally evolved as antifibrotic players in the development and progression of chronic kidney diseases and ESRD in which RT is required. The goal of this review is to highlight the role of MMPs as biomarkers in RT; their impact on the rejection process and therefore longevity of the graft; on the therapeutic regimen and on the delayed graft function. We found that MMP-1, MMP-2, MMP-7, MMP-9 and MMP-20 have impact on renal transplant and allograft rejection. They represent as new mediators involved in acute kidney transplant rejection. MMP-1, MMP-7, MMP-9, and MMP-13 represent as potential molecular allograft rejection markers. MMP-9 was also found associated with delayed graft function. Complementary therapy of allograft rejection and pre-transplant allograft outcome can be predicted due to enhanced allograft survival in mutant allele carriers for MMP-2.

Keywords: Renal transplantation; Allograft rejection; Biomarkers; Delayed Graft Function; Matrix metalloproteinases (MMPs).


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)