EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

A REVIEW ON NOVEL APROACHES FOR THE TREATMENT OF TUBERCULOSIS

Prince Srajal*, Shalini Kesharwani, Vidyakant Kushwaha, Vivek Dwivedi, Shahnawaz Sameem, Suresh Kumar Nair

ABSTRACT

Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis (Mtb). Approximately one third population of the world is infected by M. tuberculosis. M. tuberculosis was first identified by Robert Koch in 1882. Although TB usually affects the lungs but it also affects other organ such as kidneys, spine and brain. The major symptoms of TB are persistent cough with or without expectorant, loss of appetite, intermittent fever, weight loss, chest pain and haemoptysis. More complicated and common Mtb infection is coinfection with HIV due to drug-drug interaction. Currently the drugs that are used for the treatment of TB include rifampin, isoniazid, pyrazinamide, ethambutol and streptomycin. These drugs associated with one or more limitations like duration, complexity of treatment, adverse reaction, efficacy and toxicity of second line drugs etc. that cause patient compliance. A number of new molecules such as diarylquinaline (TMC-207), oxazolidionones (PNU-100480, linezolid), ethylenediamine (SQ-109), pyrroles (LL-3358) and nitroimidapyran (OPC-67683, PA-824) have exhibited potent anti-bacterial properties in vitro and are in various clinical stages of development.

Keywords: diarylquinaline (TMC-207), oxazolidionones (PNU-100480, linezolid), ethylenediamine (SQ-109).


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 March 2019 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR MARCH ISSUE PUBLISHED

    MARCH 2019 Issue has been successfully launched on 1 March 2019

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 4.161 to 4.897 due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)