PHARMACOEPIDEMIOLOGICAL ASSESSMENT OF INSULIN THERAPY IN TYPE 2 DIABETES MELLITUS PATIENTS

Binu Mathew*, Elizabeth A. M., M. Rajkumar Reddy, Adeena Balkees, H. Doddayya and S. S. Antin

ABSTRACT

Insulin administration was found to be better choice for diabetic patients who started surviving for longer periods with diabetes. The study aims to assess the prescribing pattern of insulin therapy among Type 2 Diabetes Mellitus Patients. A retrospective case analysis was conducted in medical record department of tertiary care teaching hospital. A total of 190 case records of diabetic patients with insulin therapy were reviewed and evaluated using descriptive statistics, mean and standard deviation. Out of 190 study population, male patients were more (52.63%). More number of prescriptions prescribed for the age group of 40-60 years (48.96%) with a mean ± SD of age 54.11 ± 12.26. Most of them were diabetic (60.53%) followed by pre-diabetic (22.63%) with a mean ± SD of GRBS range 246.61 ± 109.72. More number of prescriptions were with only insulin (56.32%) than in combination with OHA (43.68%). The most common insulin preparation was found to be insulin human actrapid (70.53%). Most of the prescription containing insulin actrapid and insulin mixtard (82.35%) followed by Insulin actrapid and insulin NPH (11.76%). The most commonly prescribed OHA was biguanides (47.17%). The most commonly prescribed combination of OHA was Biguanides + Sulphonylureas. We found that drug utilization pattern of insulin was optimal and effective, which helps to reduce high blood sugar level and to prevent further complications.

Keywords: Diabetes Mellitus, Insulin, OHA, Pharmacoepidemiology.