EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EVALUATION OF IN VITRO LIPID PEROXIDATION INHIBITION ACTIVITY OF HEPATOPROTECTIVE POLYHERBAL FORMULATION

Jayachandra Kuncha*, Thirugnanasambantham P., Kumaran S., Narayanan N. and Sharmila Devi V.

ABSTRACT

The free radicals are the agents which causes cell membrane damage which leads to formation of lipid hydroxyl and peroxy radicals. This is the primary process in cellular damage. The lipid peroxidation process can preventing through supplying scavengers of free radicals. This is the ultimate reason for supplying antioxidants. Botanicals are the wide source of antioxidants available in nature. The main objective of this study is to evaluate anti-lipid peroxidation activity of the hepatoprotective polyherbal formulation (LVR05) by in vitro method. The results shows effective anti-lipid peroxidation activity in dose dependent manner. The maximum lipid peroxidation inhibition was 80.89% at the concentration of 500 μg/ml, at the same concentration standard ascorbic acid shows 91.75% of inhibition. The IC50 values of sample and standard was found 112 μg/ml and 65.74 μg/ml. Based on the results it has been concluded that the polyherbal formulation is effective in prevention of lipid peroxidation. Further work is in progress towards identification and quantification of phytochemicals present in the formulation.

Keywords: In vitro Lipid peroxidation inhibition, Polyherbal formulation, Free radicals, Phytochemicals.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)