EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

SERUM IGE AND ABSOLUTE EOSINOPHIL COUNT AS PROGNOSTIC MARKER OF ALLERGIC RHINITIS: A CLINICAL STUDY IN A TERTIARY CARE HOSPITAL

Dr. (Mrs) Kalpana Sharma and Dr. Pradeep Singh Rawat*

ABSTRACT

Introduction: Allergic rhinitis is chronic condition with an estimated prevalence of 20%, as per Allergic Rhinitis and its impact on Asthma (ARIA) guidelines. Owing to lack of parameters or prognostic markers to determine the optimum therapy. The condition is treated by conventional drug therapy. The aim is to establish the role of serum IgE and Absolute Eosinophil Count (AEC) as prognostic markers for optimization of therapy. Materials and methods: 50 patients with allergic rhinitis were enrolled and treated according to the step wise therapeutic approach of ARIA guidelines. Pre and Post therapeutic value of serum IgE and AEC was measured. The severity of symptoms was measured using Total 5 Symptom Score(T5SS) at the end of 1, 2, 3, 4 and 6 months. Wilcoxon rank test was used to find the significance of change in the T5SS and Chi-square has been used to find the significance of study parameters. Result: Study shows most common age group of allergic rhinitis was between 18-38 years with female predominance (60%). The mean pretherapeutic serum IgE and AEC was 312.48IU/mL and 441.94 cells/mm3 which reduced to 99.55IU/mL and 286.66 cells/mm3 in post therapeutic condition respectively, with p value of <0.05 which was statistically significant. Conclusion: Serum IgE is a better prognostic marker then AEC. For the remission of symptoms, the values of serum IgE and AEC post therapeutically should be in normal range.

Keywords: Allergic rhinitis, Serum IgE, AEC.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)