EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

A RANDOMIZED, SINGLE CENTRIC, SINGLE ARM, OPEN LABEL STUDY TO EVALUATE THE EFFICACY AND SAFETY OF THYRO-Q IN HYPOTHYROID PATIENTS ON THYROID HORMONE THERAPY

Dr. D. M. Ravi Chand* and Dr. M .V. Rama Mohan Rao

ABSTRACT

Thyroid disorders are common in the general population and contribute to significant health issues. Therefore, it is practical to diagnose and treat so as to prevent complications arising from its imbalance using one of its kind Ayurvedic modulator to combat hypothyroidism. The present study is aimed to examine the effects of fine titration of thyroxin dosage on symptoms of hypothyroidism, wellbeing and quality of life. A randomized, single centric, single arm, open label study was designed to evaluate the efficacy and safety of Thyro-Q in hypothyroid patients along with thyroid therapy. This is a randomized, single centric, single arm, open label study to evaluate the efficacy and safety of Thyro-Q in hypothyroid patients on thyroid hormone therapy. A total of 30 subjects aged 18- 60 years were enrolled in the study. All subjects underwent investigator evaluation to check if they were eligible to participate in the study. Safety assessment- Clinical examination and vital signs evaluation, Safety and tolerability was also assessed by graded scores for treatment satisfaction, Treatment preference and Quality of life. The hypothesis is that symptoms of hypothyroidism, wellbeing and quality of life will be improved in thyroxin-treated subjects when serum thyrotrophic (TSH) is suppressed and in the lower reference range, compared to when TSH is in the upper reference range and to identify the change in quality of life by using Health Related Quality of Life questionnaire (HRQOL- SF-36). The results shows us a change 17.06% from baseline observation to day 120 observation of TSH levels , this shows how well the drug is effective in bringing the thyroid levels to the normal range, to show the trend of how effective the drug is we have further classified baseline day to 120th day into two durations where duration 1 is baseline day to the 75th day (both drug and Thyro Q for a period of 75 days) and duration 2 is 75th day to 120 day( Thyro-Q only for 45 days ) , we see that there is a 7.5% change from baseline day to 75 day when Thyro-Q is taken along with Thyroxin and 10.33 % change from 75th to 120 day when Thyro-Q is taken alone, which indicates that if the Thyro- Q intervenes well with regular medications prescribed like thyroxine, and Thyro-Q, if used for a longer duration there will be a significant control to normalize the thyroid levels, there were no adverse drug reactions (ADS) reported in any of the study subjects during the study period. The study clearly demonstrates the benefit of Thyro-Q, a strong immune response system is induced. All the subjects who were treated with Thyro Q showed the levels of T3, T4 and TSH have drastically reduced by 24.67 %, 21.93 % and 17.06 % respectively. The results has a direct impact on the well begin of the patients in terms of life style, family pressure, beginning irrational and we observed the reduction in symptoms like dryness, blurred vision, swollen hand and neck, dry and itchy skin, felling lethargic. The subjects were able to perform their own duties and were not dependent on family or friends in taking care of tasks. They were no occurrences of adverse events like flu or gastroenteritis during the study period.

Keywords: Hypothyroid, thyroid, hormone and therapy.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)