EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

IMMUNOLOGICAL PROFILE (GAD, ICA, INSULIN RECEPTOR ANTIBODIES) IN TYPE ? DM PATIENTS, OUR EXPERIENCE AT KHMC

*Dr. Lamees Abasi, Dr. Bahieh Al-Abadi, Dr. Mansour Al-Hiary, Dr. Maha Al-Amer, and Dr. Khaldoun Alsraiheen

ABSTRACT

Objective: The aim of this study was to determine the frequency of autoantibodies among Jordanian patients with diabetes mellitustype 1. Methods:A total of 128 subjects were included with age range between 1year and 14 years, 45.3% (58) of which were female and 54.7% (70) were male.Samples were analysed for anti-Glutamic acid decarboxylase, anti-insulin, and anti-islet cell antibodies using mosaic pancreas (monkey)/cerebellum (monkey) instructions for the indirect immunofluorescence assay, Euroimmun, Germany. Results:One hundred and twenty eight subjects with T1DM were enrolled in study; 58 female (45.3 %) and 70 male (54.7%). The overall frequency of any autoantibodies was 36.7% (47 of 128 subjects).Anti-GAD, anti- Islet cell and anti-insulin antibodies were detected in 30.46% (39 subjects), 25.78% (33 subjects), and 23.43% (30 subjects) respectively table-1. Anti-GAD and anti-islet cell antibodies were more frequent in male, and anti-insulin antibodies were more frequent in female's figure 1, 2, 3. Frequency of multiple antibodies more than one was observed in 38 patients (29.68%); whereas one antibody (anti-insulin antibodies) observed in 28 patients (21.87%). 18 of 19 subjects with positive anti-GAD antibodies had positive anti-islet cell antibodies. Conclusion:about one third of diabetes mellitus patients from Jordan had presence of autoantibodies such as anti-GAD, anti-islet cell, and anti-insulin in a single form or in a combination, which is suggest of having diabetes mellitus type 1. We recommend further large studies to be done in different areas of country.

Keywords: Diabetes mellitus, autoimmunity, autoantibodies.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)