EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTIFUNGAL ACTIVITIES OF AN EXTRACT AND CREAM FORMULATION OF COLA MILLENII K. SCHUM. IN DERMATOPHYTE-INFECTED WISTAR RATS

T. S. Agidigbi*, T. O. Lawal, T. O. Ajala, O. A. Odeku and B. A. Adeniyi*

ABSTRACT

Objective: Cola millenii K. Schum (Malvaceae) bark have found use in traditional medicine for the treatment of skin infections such as ringworm and scabies. The present study aimed to evaluate the In vitro and In vivo antifungal potentials of extract and cream formulations of Cola milleni K. Schum. bark in dermatomycoses-infected wistar rats. The antifungal activities of methanol extract and formulated cream containing the bark extract of C. millenii were investigated in vitro and in vivo against Trichophyton interdigitalis, T. rubrum, and Epidermophyton floccosum. Susceptibility testing and the minimum inhibitory concentrations (MIC) were determined by the agar diffusion and agar dilution methods, respectively. In vivo, male wistar rats infected with T. rubrum were treated with the formulated cream and the efficacy assessed using the empirical clinical assessment score. Histopathology using periodic acid schiff (PAS) staining technique and the haematoxylin and eosin (H&E) staining techniques were used to monitor the therapeutic efficacy. In vitro, the methanolic bark extract had activity against all three dermatophytes with an MIC between 50- 75 μg/ml. Antimicrobial susceptibilities of the extract and cream formulations showed a dose-dependent response against the dermatophyte’s species tested. Treatment of T. rubrum infected-rat with methanol extract and the formulated cream induced the clearance of fungal hyphae from the skin tissue and effected wound healing by day 17 (8 days of treatment regime) compare to control groups. These findings suggest that the extract and cream of Cola millenii have antifungal activities and are effective against commonly occurring dermatophytes.

Keywords: Cola millenii, dermatophytes, antifungal, skin infection, Cola millenii cream.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)