EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

BACOPA MONNIERI (BRAHMI) – WHAT IS THE EVIDENCE IN RELATION TO COGNITION, MEMORY AND MOOD? A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMISED CONTROLLED TRIALS

Dr. Emma Derbyshire PhD*

ABSTRACT

Ethnopharmacological Relevance: Previous research suggests that Bacopa monnieri has potential to improve cognition, particularly speed of attention.[1] The present article aims to update previous work and re-evaluates the evidence on Bacopa monnieri and cognitive function. It also considers the wider effects of Bacopa monnieri on memory and mood. Materials and Methods: PubMed, the Cochrane Library and ClinicalTrials.gov were searched to identify relevant RCTs using specified search terms. Reference lists of identified articles were also reviewed. Trials identified were objectively assessed for methodological quality using the Cochrane risk of bias tool and Jadad scale. Trials administering Bacopa monnieri in combinative with other active ingredients were excluded. Results: Thirteen studies met the inclusion criteria comprising of 685 subjects. Overall 11 studies had a low risk of bias and were regarded as good quality. Meta-analysis using data from 160 subjects showed improved State-Trait Anxiety for which there was no evidence of heterogeneity between studies (I2=0%, p=0.58) and which was significantly reduced in the experimental group by -2.94 (95% CI: -3.97 to -1.92), p<0.0001. No significant findings were observed for the delayed recall Auditory Verbal Learning Task, Digital Span Forwards or Digital Span Backwards tests. Conclusion: This updated review suggests that Bacopa monnieri including the standardised CDRI 08 extract could help to reduce feelings of anxiety. These are promising findings and build on previous work observing cognitive benefits. Ongoing trials using aligned definitions of cognitive, memory and mood domains and evaluating the adjunctive or „head to head‟ effects of Bacopa monnieri against conventional medications are also needed.

Keywords: Bacopa monnieri, nootropic effects, cognition, attention, memory, mood, anxiety.

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