THE POSSIBILITIES OF MOLECULAR DIAGNOSIS OF ALLERGIC DISEASES

Dzhambekova G. S.*

ABSTRACT

Molecular diagnosis of allergy (MDA) is becoming more common in everyday clinical practice, and today more than 130 allergen molecules are commercially available for testing specific immunoglobulin E (sIgE) in vitro. The results of all sIgE tests related to the molecular diagnosis of allergy should be analyzed taking into account the clinical history, since sensitization to the allergen does not always imply clinical manifestations. Clinicians and immunologists specializing in the field of allergology should be aware of all the latest advances in the molecular diagnosis of allergies. The MDA strategy is based on the identification of sensitization to allergens at the molecular level using natural purified or recombinant allergen molecules. Thus, molecular diagnostics technologies are becoming an integral part of clinical practice, which allow improving the accuracy of diagnosing and predicting the course of allergies, playing an important role in three key aspects of allergy diagnostics: they allow differentiating true sensitization and sensitization due to cross-reactivity in multivalent sensitization and thereby identifying allergens -inductors.

Keywords: allergic diseases, molecular diagnostics, allergens, antibodies.