EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

A STUDY OF THE EFFECT OF VERNONIA AMYGDALINA LEAF EXTRACT ON GLUCOSE AND HISTOLOGY OF THE PANCREAS IN ALLOXAN INDUCED ALBINO RATS

Brisibe Ngozi, Nwachuku Edna Ogechi and Elekima Ibioku*

ABSTRACT

Diabetes mellitus is a chronic disease caused by insulin deficiency by pancreatic β cells or due to inability to respond to insulin produced leading to high blood glucose concentrations which may result in damage of some body organs including blood vessels and nerves. The increased prevalence of diabetes mellitus in Africa has necessitated the quest for natural remedies for its treatment and management. This work tested the efficacy of Vernonia amygdalina leaf extract (Bitter leaf) on alloxan induced diabetic rats as well as demonstrated the histological features of the pancreas when not induced or treated, induced and untreated then induced and treated. The study was carried out on 34 adult albino Wister rats which were divided into three (3) groups; A (neither induced nor treated), B (induced and untreated), and C (induced and treated). Comparisons between groups A (6.15±0.85) mmol/l and B (9.81±3.76) mmol/L showed fasting blood glucose significantly high and between A and C (induced and treated with 1.6g/kg bodyweight of Vernonia amygdalina extract), there was no significant change in the fasting blood glucose level (P=0.4545). Comparison between groups B and C (6.41±0.53) showed fasting blood glucose level significantly decreased t (P=0.0036). Furthermore, the research indicated histologically that Vernonia amygdalina extract ameliorated the damage caused by the diabetogen (alloxan) on islets β cells of Langerhans in the pancreas upon administration of the leaf extract for 21 days on daily basis.

Keywords: Diabetes mellitus is a Vernonia amygdalina leaf extract for 21 days on daily basis.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)