FORMULATION AND EVALUATION OF ANTISEPTIC FILM FORMING LIQUID FOR SKIN INJURY
Pooja Hemane*, Dr. Vinita Kale1 and Tirupati Rasala2
Objective-The localized treatment of body tissues, skin diseases, injury and wounds requires that the particular pharmaceutical components be maintained at the site of treatment for an effective period of time but dermatological administration of creams, foams, gels and lotions are considered to reside for a relatively short period of time at the targeted site. To overcome this problem here the approach chosen for the new dosage form is a in-situ film forming polymeric formulations. On the skin surface this formulation solidifies into a film which is able to deliver the active moiety to the skin. Materials-Materials used for this dosage form are Eudragit L-100, Polyethylene glycol, Isopropyl alcohol, 6.8 phosphate buffer and Povidone-iodine (API). Methods- Methods used are Solvent casting method and Spray method. Conclusion-The formed film was sufficiently substantial to provide a sustained drug release to the skin and prevent the deposition of dust particles which reduces the chances of further infection. Result-Prepared films were evaluated by evaluation parameters appearance, thickness of film, drying time, moisture absorption, water vapor transmission, folding endurance, weight variation, in vitro drug diffusion study.
Keywords: In-situ film, Drug diffusion, Solvent Casting, Skin, Sustained release.
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