EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTI HYPERTENSIVE DRUGS FOR PULMONARY ARTERIAL HYPERTENSION (PAH) IN INTERNATIONAL PHARMACOVIGILANCE: DATA MINING STUDY

V. Lavanya*, Y. Anil Kumar, Konda Ravi Kumar and K. S. D. V. Surya Kiran

ABSTRACT

Precapillary pulmonary hypertension with a mean pulmonary artery pressure of >25 mm Hg and a normal pulmonary artery wedge pressure of <15mmhg is pulmonary arterial hypertension signs and symptoms of PAH are similar to those of heart & lung conditions. The prevalence of PAH is thought to be range of 15-50 subjects per million population in Europe. Biological factors, chemical factors genetical factors are the confounding risk factors for PAH drug use PAH can be associated with exposure to certain drugs or toxins, particularly to appetite suppressant intake drugs. PAH is a disease of precapillary pulmonary arterial bed, including the medium sized pulmonary arteries &pulmonary arteriols characterized by vascular obliteration widespread endothelial apoptosis result in proliferation of apoptosis resistant endothelial precursor cell & that proliferate & eventually form plexiform lessions PAH has a genetic component. The bone morphogenetic proteins (BMP) are part of the transforming growth factor superfamily (TGF-BETA). The disfunctional pulmonary hypertensive endothelial cell phenotype is characterized by uncontrolled proliferation increased production of vasoconstrictor mediators such as endothelin expression of 5-lipoxygenase & decreased synthesis of prostacyclin CCBS, ERAS,PD5 inhibitors, guanylate cyclase stimulators, prostacyclin IP receptors agonists are used for treatment of PAH.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)