EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

DEVELOPMENT AND VALIDATION OF NEW UV METHOD FOR SIMULTANEOUS ESTIMATION OF TADALAFIL IN COMBINATION WITH DAPOXETINE HYDROCHLORIDE IN A PHARMACEUTICAL DOSAGE FORM

T. Sudha*, N. Bhuvaneswari, S. Geetha, S. Mohanapriya, S. Nivedhitha and S. Nanthini

ABSTRACT

Objective: The present research studies describe development and validation for the simultaneous determination of Tadalafil and Dapoxetine hydrochloride in bulk and in tablet dosage form. Method: Simple UV spectrophotometric method has been developed for simultaneous estimation of Tadalafil and Dapoxetine hydrochloride in bulk and in tablet dosage form. For the method, stock solutions were prepared by using acetonitrile: water (50:50) and the absorbance maxima for Tadalafil and Dapoxetine hydrochloride were found to be 284nm and 292nm respectively. Results: A linear response was absorbed in the range of 1 to 15ug/ml and 3 to 45ug/ml with correlation co-efficent of 0.9997 for Tadalafil and 0.9998 for Dapoxetine respectively. The percentage purity of the tablet formulation was found to be 103.4% and 99.99% for Tadalafil and Dapoxetine respectively. Conclusion: The method was validated for the different parameters like accuracy, precision, sensitivity and linearity as per ICH guidelines Q2 (International Conference Harmonisation). This method can be used for the simultaneous estimation of Tadalafil and Dapoxetine hydrochloride in quality control of formulation without interference of excipients.

Keywords: Simultaneous determination, Tadalafil, Dapoxetine, UV-spectrophotometer, ?max.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)