EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

MMP-2, MMP-9, AND VEGF LEVELS IN PATIENTS WITH RENAL CELL CARCINOMA: ROLE AS POTENTIAL BIOMARKERS FOR EARLY PROGNOSTICATION OF DISEASE

Shamim Ahmad*, Vishwajeet Singh, Rahul Janak Sinha, Aneesh Srivastava, Anil Mandhani and Priyank Yadav

ABSTRACT

Aim: The aim of this study was to observe the levels of Matrix Metalloproteinases-2 (MMP-2), Matrix Metalloproteinases-9 (MMP-9), and Vascular endothelial growth factor (VEGF) prospectively, in patients with renal cell carcinoma (RCC), and assess their impact on patient survival, to establish them as biomarkers for prognosticating disease. Material and Method: 100 patients with RCC who were planned for surgery included in this study. Their venous blood sample was collected before and after the surgery to analyze the level variation of MMP-2, MMP-9, and VEGF using ELISA (enzyme-linked immunosorbent assay) technique. All patients were followed up at every three months for up to 5 years. Blood samples of healthy kidney donors were taken to serve as the control for the study. The survival analysis was done with Kaplan–Meier survival curves. Results: Preoperative MMP-2, MMP-9, and VEGF levels were higher compared to the postoperative levels in patients with RCC (p=0.001).On further analysis, higher marker levels, high-grade tumor, advance stage tumor and tumor size >7 cm were associated with low overall survival and progression-free survival (p=0.001). Conclusion: Level variation of MMP-2, MMP-9, and VEGF correlate with survival of patients with RCC in different conditions. They may serve as a useful biomarker for prognosticating patients with RCC in the early stage for achieving better survival.

Keywords: RCC, MMP-2, MMP-9, VEGF, OS, PFS.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)