INVITRO STUDY ON ANTIDIABETIC, ANTIOXIDANT, ANTI-INFLAMMATORY, ANTI-OBESITY PROPERTIES OF POLYPHENOL RICH FRACTION FROM THE LEAVES OF ORTHOSPHON STAMINEUS
H. Aswini*, G. Nithya and K. Shoba
Orthosiphon stamineus is a medicinal plant including various type of plant used in herbolism and some of these plants have a medicinal activities. Medicinal plants are the “backbone” of traditional medicine. The plant treated to the many diseases including Diabetes, Antioxidant, Inflammatory and Obesity. O. stamineus (distilled water, 50% aqueous methanol, methanol, 70% aqueous acetone and chloroform extracts) have been tested for free radical-scavenging activity, using a 1,1-diphenyl-2-picrylhydrazyl in vitro model system. The highest activity was found in acetone extract. This showed its anti oxidative potency was comparable with quercetin and butylated hydroxylanisole (BHA). They also proved using different in vitro method (superoxide scavenging and xanthine oxidase) that O. stamineus extract showed potential antioxidant activity. They were tested for antioxidant activity using inhibition of NO production in LPS-activated. Mostly 60-75% of the medicinal species of Orthosiphon have been traditionally used for treatment of inflammation and diseases like arthritis, bronchitis and rheumatoid. The pharmacological activity of the species of genus Orthosiphon provides primarily in vivo information for anti-inflammatory effects. The polyphenol rich fraction from leaves of Orthosiphon stamineus was inhibiting the pancreatic lipase most widely studied mechanism for the identification of potential anti obesity agents.
Keywords: Anti oxidative, butylated hydroxylanisole, quercetin, Orthosiphon stamineus, polyphenol.
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