EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTIDIARRHEAL STUDY OF METHANOL LEAF EXTRACT OF ANTHOCLEISTA DJALONENSIS

Ozioko Faith Obinna and Kagbo Hope Delesi*

ABSTRACT

The anti-diarrhoeal properties of methanol leaf extract of Anthocleista djalonensis on diarrhoea models (castor oil induced diarrhoea and castor oil induced fluid accumulation and intestinal transit models) were evaluated in rats. Five groups of five rats each were fasted for 18h and given 1ml/kg distilled water, 250, 500 and 1000mg/kg of the extract and 5mg/kg Loperamide respectively. The extracts caused a significant (p<0.001) decrease in the number of faecal matter passed and intestinal fluid accumulated in the castor oil-induced diarrhea and entreopooling models respectively, with 28.07 – 84.21% inhibition of defecation and 37.18 – 64.53% inhibition of intestinal fluid accummulation respectively in the two models. Furthermore, there was significant (p<0.01– p<0.001) decrease in intestinal transit in the castor oil-induced intestinal transit model with 28.71 - 68.51% inhibition of propulsive movement of the small intestine. From the foregoing, Anthocleista djalonensis leaf extract has been shown to inhibit the severity of diarrhoea, reduce water and electrolyte secretion into the small intestine and decrease intestinal transit. These findings lend credence to the use of the leaf of the plant in traditional medicine for the management of diarrhoea in some communities in Nigeria.

Keywords: Anthocleista Djalonensis, Diarrhoea, Castor Oil, Entreopooling, Intestinal Transit.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)