EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

28-HOMOCASTASTERONE ATTENUATED DIABETIC KIDNEY DISEASE BY MODULATING LIVER X RECEPTOR AND TUMOR NECROSIS FACTOR-ALPHA PROTEIN EXPRESSION IN STZ-INDUCED DIABETIC RAT.

Athithan Velan and Srikumar Kotteazeth*

ABSTRACT

28-Homocastasterone (28-HC) exhibited antiglycemic and antilipidemic effects in diabetic rat. In the present study evaluated 28-HC effects on Liver x Receptor (LxR) mRNA expression, antioxidant status and histomorphological changes in diabetic rat kidney. Induction of diabetes was achieved by a single peritoneal injection of STZ (60 mg/kg. bwt) and 100 μg of 28-HC were administrated orally for 15 days. Followed by tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase, reduced glutathione (GSH), tumor necrosis factor-α (TNF-α), LxR-α, β mRNA and protein expression, tissue histomorphology were analysed along with 28-HC affinity towards inhibitor binding side of COX2 enzyme were evaluated using molecular simulation software. Increased SOD, catalase, reduced GSH, LxR-α and β mRNA levels were noted and reduced levels of MDA and TNF-α protein were registered in 28-HC treated diabetic rat. Kidney histology observed that glomerular damage reduced in 28-HC treated diabetic rat, In Silico analyses detected 28-HC have significant affinity towards inhibitor binding site of COX2 enzyme. 28-HC enhancing antioxidant enzymes catalytic activity thus attenuated lipid peroxidation and glomerular damage through transactivation of LxR and inhibition of COX2 enzyme catalytic activity. It is suggested that 28-HC supplemented diet prevent diabetic renal disease in man.

Keywords: 28-Homocastasterone, Diabetic, Kidney, LxR, COX2.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)