EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

A PILOT STUDY ON THE PREVALENCE AND ASSOCIATION OF GPRC6A SINGLE NUCLEOTIDE POLYMORPHISMS IN SOUTH INDIAN PATIENTS WITH METABOLIC SYNDROME, METABOLIC SYNDROME AND INFERTILITY

Balaji Ramanathan, Kumaravel Velayutham#, Sridhar Kesavan, Karthikeyan Muthusamy, Lakshmanan Loganathan, Rohini Gomathinayagam*

ABSTRACT

Aims: The G protein coupled receptor, class C, GPRC6A is identified to primarily modulate metabolic functions and reproductive health in males. The single nucleotide polymorphisms (SNPs) of GPRC6A rs2274911 and rs143913245 (F464Y) are reported to be associated with metabolic syndrome, infertility. However, there exists a lacuna in the knowledge regarding the incidence, prevalence of these SNPs in the Indian/south Indian population and hence the present study focuses to determine their influence in the metabolic syndrome (MTS), MTS and infertility patients. Materials and Methods: Genomic DNA from peripheral blood samples of healthy female/male controls, diabetic/obese male controls and patients with MTS, MTS and infertility were isolated and GPRC6A gene regions corresponding to exon 2, exon 4 were PCR amplified and sequenced. Results: Genotyping results revealed that rs2274911, rs6917467 was incident in the assessed population and that the percentage of rs2274911 wild type carriers (GG) significantly differed between the non-diabetic and diabetic groups (GG, p<0.01). Further, on comparison with the non-diabetic patients with MTS, the diabetic patients with MTS, diabetic patients with MTS and infertility (p<0.05; p<0.001 respectively) tended to present a significantly higher percentage of the rs2274911 heterozygous GA alleles. Conclusion: The GPRC6A rs2274911 is of frequent incidence in patients exhibiting metabolic abnormalities, infertility. Screening for GPRC6A in diabetic/ MTS, infertility patients will aid better therapeutic regimens and management of these disorders.

Keywords: GPRC6A, SNP, F464Y, MTS (Metabolic Syndrome), Ocn (osteocalcin).


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)