EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

A NOVEL MODEL OF PSYCHOGENIC HYPERTENSION: EFFECT OF A YET ANOTHER PLEOTROPIC BETA BLOCKER OR JUST MIMICRY?

Dr. K. Bhuvaneswari*, MD, C.K. Harshith Priyan, Dr. Ramanujam Narayanan, MD

ABSTRACT

Background: Hypertension is one of the leading causes of disability and death. Stress is a major etiology affecting both young and older age groups. Nebivolol is a 3rd generation beta blocker with additional vasodilatory effects due to endothelial NO production. Objectives: The current study aims to develop a model of stress induced chronic, psychogenic hypertension in male Swiss albino mice using restraint induced stress. This study also aims to evaluate the pharmacological effects of the beta blocker in this model. Methods: 4 groups (n=6) of albino male mice were selected and allowed immobilization for 2 hours daily using the restrainers. Weekly BP and HR were measured till there is maximum persistent increase in systolic BP more than 20 mm Hg from baseline level and observed for its hypertension persistence phase and how this declines due to adaptation that animals will undergo during stress phase. Among groups after inducing hypertension, one group was kept for hypertension control; the remaining three were used for influence of Nebivolol without stress, with stress and for the diluent control CMC. Outcomes and Results: A pilot development of a novel model of psychogenic hypertension was undertaken over nine weeks in the mice. Additionally the efficacy of the antihypertensive effects of nebivolol was compared with its other pleotropic effects in the cardiovascular and central nervous systems and was found to be significantly high. Conclusion: We have developed a novel psychogenic hypertension model induced by restraint stress in mice.

Keywords: Nebivolol, Psychogenic hypertension, restraint-stress, hypertension model, Noninvasive blood pressure, beta receptors.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia