A NOVEL MODEL OF PSYCHOGENIC HYPERTENSION: EFFECT OF A YET ANOTHER PLEOTROPIC BETA BLOCKER OR JUST MIMICRY?
Dr. K. Bhuvaneswari*, MD, C.K. Harshith Priyan, Dr. Ramanujam Narayanan, MD
ABSTRACT
Background: Hypertension is one of the leading causes of disability and death. Stress is a major etiology affecting both young and older age groups. Nebivolol is a 3rd generation beta blocker with additional vasodilatory effects due to endothelial NO production. Objectives: The current study aims to develop a model of stress induced chronic, psychogenic hypertension in male Swiss albino mice using restraint induced stress. This study also aims to evaluate the pharmacological effects of the beta blocker in this model. Methods: 4 groups (n=6) of albino male mice were selected and allowed immobilization for 2 hours daily using the restrainers. Weekly BP and HR were measured till there is maximum persistent increase in systolic BP more than 20 mm Hg from baseline level and observed for its hypertension persistence phase and how this declines due to adaptation that animals will undergo during stress phase. Among groups after inducing hypertension, one group was kept for hypertension control; the remaining three were used for influence of Nebivolol without stress, with stress and for the diluent control CMC. Outcomes and Results: A pilot development of a novel model of psychogenic hypertension was undertaken over nine weeks in the mice. Additionally the efficacy of the antihypertensive effects of nebivolol was compared with its other pleotropic effects in the cardiovascular and central nervous systems and was found to be significantly high. Conclusion: We have developed a novel psychogenic hypertension model induced by restraint stress in mice.
Keywords: Nebivolol, Psychogenic hypertension, restraint-stress, hypertension model, Noninvasive blood pressure, beta receptors.
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