EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

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 ICV - 79.57

Abstract

SYNTHESIS, CHARACTERIZATION, IN VITRO ANTI INFLAMMATORY ACTIVITY AND QSAR EVALUATION OF BENZOTRIAZOLYL)-3-{5-(CARBOXYMETHYL) DIAZENYL] -2-HYDROXYPHENYL}PROP-2-ENOIC ACID DERIVATIVES

C. M. Jamkhandi*, J. I. Disouza, S. B. Magdum, K. B. Swami, P. S. Kumbhar

ABSTRACT

Synthesis of Benzotriazol-1-yl-3-{5-[(E)-(carboxymethyl) diazenyl]-2-hydroxyphenyl}prop-2-enoic acid derivatives based on diazonium coupling reaction. The five derivatives from Ie to Ve obtained by diazonium coupling reaction with various amino acids through intermediate compound (2E)-2-(1H-benzotriazol-1-yl)-3-(2-hydroxyphenyl)prop-2-enoic acid. The synthesized derivatives were characterized on basis of physical, chemical properties, TLC, IR, NMR and Mass spectral data. All the derivatives evaluated for in vitro anti-inflammatory activity. Quantitative Structural Activity Relationship (QSAR) was analyzed using set of predictor variables like physicochemical parameters and response variables like in vitro anti-inflammatory activity data. The data obtained reveal the derivatives IIe showed remarkable % inhibitory activity of protein precipitation, IIIe, Ve showed good and Ie, IVe exhibited moderate percentage of inhibition in comparison with standard.

Keywords: Benzotriazole, Diazonium Coupling Reaction, Condensation reaction, benzotriazole derivatives, anti-inflammatory activity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia