EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ANTIOXIDANT-MEDIATED GLUTATHIONE LEVELS OF SICKLE ERYTHROCYTES UNDER DRUG-INDUCED OXIDATIVE STRESS.

Aloh, G. S, *Obeagu, Emmanuel Ifeanyi, Okoroiwu, I.L., Odo, Christian Emeka, Odo Matthew Chibunna, Kanu,S.N, Elemchukwu, Q., Okpara,K.E., Ugwu, Getrude Uzoma,

ABSTRACT

The effects of two antioxidants, ascorbic acid and α-tocopherol, on the glutathione (GSH) levels of sickle erythrocytes were studied before and after inducing oxidative stress with 5mg of acetylphenylhydrazine (APHZ) per ml of blood. Pre –APHZ GSH levels of the control and sickle erythrocytes were 39.82 + 1.48 mg/100ml and 26.00 + 2.32 mg/ml respectively. Their respective post – APHZ levels were 37.00+ 2.35 mg/ml and 13.00 + 1.98 mg /ml. Post – APHZ +ascorbic acid , their mean GSH levels were respectively 37.75 + 2.50 mg/ml and 16.00 + 1.83 mg/ml , while post- APHZ + α- tocopherol significantly (p<0.05)elevated their GSH levels to 39.76 + 2.80 mg/ml and 22.00 + 2.24 mg/ml respectively. These results indicate that whether defective or not , the initial effect of an oxidant drug is to lower the GSH levels of red cells. Because the sickle erythrocytes had a subsisting redox stress ,the effect of APHZ could not be fully reversed by both ascorbic acid and α - tocopherol as occurred in the control. α – Tocopherol was more effective in counteracting the effect of APHZ , probably because it is a fat – soluble vitamin.

Keywords: Antioxidants; ascorbic acid; alpha-tocopherol; glutathione; oxidative stress; Sickle cell.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)