EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EFFECT OF METHANOL EXTRACT OF DIALIUM GUINEENSE LEAVES ON LIVER CELL DAMAGE AND LIPID PROFILE OF ALBINO RATS

Aloh,G.S., Obeagu, Emmanuel Ifeanyi, Odo Christian Emeka, Kanu Stella Ngozika, Okpara, kingsley Ezechukwu, Nwosu, D.C., Ugwu Getrude Uzoma and Ezeumudo Oluebube C

ABSTRACT

This study investigated the protective effect of oral administration of the different doses (250mg and 500mg) of methanol extract of Dialium guineense leaves against liver cell damage and lipid profile of albino wistar female rats. Analysis of the following parameters were made: alanine aminotransferase (ALT), aspartate aminotransferase (AST), Superoxide dismutase (SOD), catalase, glutathione (GSH), malondialdehyde (MDA), vitamin C (VIT.C), vitamin E (VIT.E), high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (T.CHOL), total protein (T.PROT), triacylglycerides (TAG) & albumin (ALB). Sixteen (16) albino rats were distributed into four (4) groups. Group 1(Normal control) was not subjected to hepatocyte damage, but only received normal feed and water ad libitum. Group 2 (negative control) received the 2.5ml of C6H14/CHCl3 (hepatotoxicant) but was not given the extract. Groups 3 and 4 were given the C6H14/CHCl3 and were treated with 250mg and 500mg/kg body weight extract of Dialium guineense respectively. The results indicate that the 250mg and 500mg of the extract caused elevation in total cholesterol and high-density lipoprotein significantly (P<0.05) when compared with the negative control. 250mg of extract on low density lipoprotein also increased significantly (p<0.05) in comparison with the negative control. Similarly, the effect of 250mg and 500mg of the extract on vitamin E and catalase was significantly elevated (p<0.05), whereas 500mg only caused vitamin C and SOD to increase significantly when compared with the negative control. The effect of 500mg extract on ALT and AST has significant elevation (p<0.05) when compared with the negative control. No significant difference was observed in the other parameters in comparison with the normal and control. Therefore, methanol extract of Dialium guineense did not exert a hepatoprotective effect in the rats used, and caused the unusual effect of causing cholesterol, HDL and LDL elevations.

Keywords: Metanol extracts, Dialium guineesnse leaves, liver function parameters, Lipid profile, Albino Rats.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)