EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

HEPATOPROTECTIVE AND RENAL EFFECTS OF METHANOL EXTRACT OFALBUCA NIGRITANA BULB IN FEMALE WISTAR RATS

Aloh,G.S., *Obeagu,Emmanuel Ifeanyi, Odo Christian Emeka, Kanu, Stella Ngozika, Ugwu Getrude Uzoma and Ikoro, Joseph Igwe

ABSTRACT

Methanol extract of Albuca nigritana bulb was investigated for its hepatoprotective and renal effects on hexane/chloroform induced hepatocellular damage in female wistar rats. The plant extract was administered at 250mg/kg and 500mg/kg body weight to the test groups randomized into two groups. Liver enzyme markers and important biochemical parameters were measured and compared with the positive control group. The plant extract showed no hepatoprotective effect but adverse effect on renal function as judged by the level of antioxidants, liver marker enzymes, urea, creatinine and electrolyte level in the sera of the induced experimental animals. The AST level showed a significant increase at 250mg/kg dose of the extract (p < 0.05) the level of ALT was not significantly increased (p>0.05), the level of total protein was not significantly reduced (p>0.05) and the albumin level was not significantly increased (p>0.05). The urea, creatinine and MDA levels were significantly elevated (p < 0.05). Also there was also a significant reduction in glutathione, catalase, and vitamin C and E levels (p<0.05), while only SOD showed a significant increase at a dose of 500mg/kg of plant extract (p<0.05). Finally Na⁺ and Cl⁻ showed a significant increase in the serum level (p < 0.05). Only potassium showed a non-significant increase (p>0.05). It was therefore concluded that Albuca nigritana has no hepatoprotective effect but adverse renal effect on the animals used for the study.

Keywords: Albuca nigritana, hepatoprotective effect.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)