EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EFFECT OF KIHADALACTONE ON PLASMA RECALCIFICATION TIME OF NAJA KATIENSIS AND BITIS ARIETANS VENOMS TREATED BOVINE PLASMA

*Abdullahi Balarabe Sallau, Yusuf Tauhid, Abdullahi AbdulMalik Salman, Hadiza Lawal Abdullahi, Mohammed A Ibrahim, Joyce J Kiplimo, Muhammad Lawal Buga

ABSTRACT

The effect of a limonoid (Kihadalactone) on recalcification time of bovine plasma treated with Naja katiensis and Bitis arietans venoms was investigated. The plasma recalcification time was found to be effectively reduced in a dose dependent pattern. In plasma incubated with N. katiensis venom, the highest inhibitory activity of 42.3 % at 1 mg/ml dose of kihadalactone was obtained, this was however found to decrease to a lower inhibition value of 27.3 % at 0.001 mg/ml dose.
Similarly, in plasma incubated with B. arietans venom, an inhibitory activity of 51.2 % at 1 mg/ml dose of kihadalacetone and a low activity of 33.6 % inhibition of the increase at 0.001 mg/ml were obtained. This study showed that kihadalactone, could effectively serve as an antidote for the reversal of increase in plasma recalcification time posed by both snake venoms.

Keywords: Bitis arietans, Naja katiensis, snake venom and plasma recalcification time.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)